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While this study did not include metformin as background therapy, it established tirzepatide's independent weight loss efficacy (up to 22.5% body weight reduction with the 15 mg dose at 72 weeks)

[2] Michell L., et al

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Although routine NAD quantification is not currently part of clinical practice, longitudinal incorporation of redox-related biomarkers in research settings may help determine whether fluxregeneration proportionality remains stable during prolonged therap